a tool for identifying drug-targetable redox-active disulphides

Gamma-crystallin F

Intramolecular

Cysteine 19 and cysteine 79

A redox-regulated disulphide may form within Gamma-crystallin F between cysteines 19 and 79 (18 and 78 respectively in this structure).

Details

Redox score ?

81

PDB code

Structure name

gammaf crystallin from bovine lens

Structure deposition date

1998-02-10

Thiol separation (Å)

4

Half-sphere exposure sum ?

69

Minimum pK_a ?

6

% buried

65

Peptide accession

Residue number A

19

Residue number B

79

Peptide name

Gamma-crystallin F

Ligandability

Cysteine 19 of Gamma-crystallin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Gamma-crystallin F

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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